The Biophysics and Biophotonics group
The Biophysics and Biophotonics group is working both with experimental and theoretical approaches to perform basic research on topics at the border of physics and biology. We develop experimental tools such as optical tweezers for single cell manipulation and single macro-molecule force spectroscopy. In addtion, we are working with microfluidic devices, image-processing, and high-speed imaging. To better understand the biological systems under study we also develop theoretical physical models that are solved using numerical methods. The main research is aimed at understanding bacterial adhesion from a physicist point of view. We approch research questions using a combination of experimental approaches and physical models to help elucidate on the bacterial adhesion process.
Optical Tweezers are a technique that is built upon the principle that small particles can be trapped in the waist of a strongly focused laser beam.
The trapping results from the fact that objects in the focus changes the momentum of the laser beam and thereby experience a restoring force if they try to leave the high intensity volume. Optical Tweezers can therefore be used for actively repositioning small objects with a precision that is better than the diffraction limit of modern optical microscopes. The technique works for a variety of micrometer-sized "objects", including living cells and bacteria.
The optical tweezers technique can also be used for measuring feeble forces (in the sub-pN to hundreds of pN range) in e.g., biological systems. A trapped bead (e.g. polysterene bead) behaves as a virtual micro-dynamometer.
MASTER THESIS PROJECTS (EXJOBB)
A list of currently available master thesis projects (exjobb) can be found here:
Anyone interested in our research is welcome to contact Magnus Andersson
Read more about about the technique and our activity at the old webpage: The Biophysics and Biophotonics group